Gabapentin and Tramadol: Side Effect and Adverse Drug Reaction

Gabapentin and Tramadol are two types of drugs that have different functions. In the article Gabapentin and Tramadol: Side Effect and Adverse Drug Reaction, you will find out more about the interaction of tramadol, gabapentin, as well as with other drugs.


What are Gabapentin and Tramadol?

Gabapentin is an epilepsy drug that relieves seizures. You should only purchase the capsules of the drug without a prescription from your doctor. Gabapentin is a type of anticonvulsant or anti-seizure drug. The drug affects nerves and chemical substances in the body that cause pain and seizures. Gabapentin does not cure epilepsy. It only controls seizures when taken regularly.

Tramadol is a drug that can be classified as a narcotic, not a psychotropic. The reason is that tramadol belongs to the group of opioids commonly prescribed by doctors as analgesics or painkillers and does not provide changes in the behavior of its users. Tramadol is one of the opioid agonists.


How does Tramadol work?

Tramadol works in a similar way to reduce the amount of pain that the brain thinks is going on. Keep in mind, that this type of drug is not suitable for everyone and its use should be under the supervision of a doctor.


What Side Effects Can It Cause from Gabapentin and Tramadol?


In general, gabapentin side effects are as follows:

  • Dizzy
  • Sleepy
  • Fatigue
  • Fluid retention (edema)
  • Nauseous
  • Vomit
  • Difficulty speaking
  • Jerky movement
  • Unusual eye movements
  • Double vision
  • Tremor
  • Memory loss


In addition, gabapentin can cause more serious side effects, including:

  • Weight gain
  • Joint pain
  • Drunk
  • Blurred vision
  • Viral infection

Antiepileptic drugs have been linked to an increased risk of thinking up to suicidal behavior. For anyone considering the use of antiepileptic drugs should balance the risk of suicide with clinical needs. When the patient starts therapy, the first thing to do is to be closely observed for clinical worsening, suicidal thoughts, or unusual behavioral changes.



Several side effects can appear after a person takes this drug. In general, tramadol can cause drowsiness. Therefore, if the doctor prescribes it, it is advisable not to drive, operate heavy machinery, or perform dangerous activities. In addition, tramadol can cause other side effects, such as:

  • Dizzy
  • Headache
  • Nausea and vomiting
  • Constipated
  • Lack of energy
  • Perspire
  • Dry mouth

This effect can occur in several days to several weeks. However, if the condition gets worse and does not go away, you can see a doctor to ask to stop or ask him to replace this drug with another type of the same effect.

In addition to the mentioned, Tramadol can also cause seizure effects. The risk of seizures can increase if he takes a higher dose of tramadol than recommended. The risk of seizures will be higher, especially for those users of certain antidepressants or opioid medications.

No one should use tramadol if they have severe respiratory problems, blockages in the stomach and intestines, or for you to have recently used alcohol, sedatives, and anesthetics.

Worse, tramadol can slow down to stop breathing, and may form a habit. Misuse of these drugs can lead to addiction, overdose, even death, especially in children or others who use the drug without a doctor’s prescription.


Does tramadol include narcotics? Will it be addictive?

Tramadol is narcotic and addictive. Tramadol, a Schedule IV controlled substance is associated with addiction and abuse. Tramadol may be addictive, even with a dose prescribed by a doctor. Misuse of tramadol can lead to overdose to death.

Like other opioids, people who use tramadol for a long time will experience symptoms of drug breakup if the doctor reduces the dose, or if you suddenly stop taking it.

Gabapentin and Tramadol: Side Effect and Adverse Drug Reaction

What is the Appropriate Dosage for Gabapentin and Tramadol?

Determination of gabapentin dosage depends on the condition suffered by the patient.

The following are common doses of gabapentin use for adult patients based on the conditions that they wish to address:


Seizures due to epilepsy

300 mg 1 time daily on the first day, 300 mg 2 times a day on the second day, and 300 mg 3 times a day on the third day. Depending on how the patient responds to the drug, the dose can be increased by 300 mg every 2-3 days.


Nerve pain

300 mg 1 time daily on the first day, 300 mg 2 times a day on the second day, and 300 mg 3 times a day on the third day. Depending on patient response, the dose can be increased to 300 mg every 2-3 days. Maximum daily intake is 3600 mg


Nerve pain after herpes

The initial dose is 600 mg 1 time a day, taken in the morning, then the dose is increased to 600 mg 2 times a day.


Restless leg syndrome

600 mg taken daily at 5 p.m.

To overcome seizures due to epilepsy in children over 6 years old, the initial dose given is 10-15 mg/kg bb. The maximum dose is 50 mg/kg bb.


Tramadol Dose

  • Tramadol should be taken in 50-100mg (immediate-release tablets) each 4-6 hours if you need pain relief.
  • The maximum dose is 400 mg/day.
  • To increase tolerance patients should be started with 25 mg/day, and the dose can be increased 25-50 mg every 3 days until it reaches 50-100 mg/day every 4 to 6 hours.
  • The recommended dosage for extended-release tablets is 100 mg daily, which can be increased by 100 mg every 5 days, but not exceeding 300 mg/day. To change from an immediate release to an extended-release, the total daily dose should be rounded down to the nearest 100 mg. Extended-release tablets must be taken whole.
  • Tramadol is available with or without food.


What medications interact with Gabapentin and Tramadol?

Interactions can occur when gabapentin is used in combination with other drugs. The medicines in question are:

  • Opioid painkillers, such as morphine. This can lead to a higher risk of central nervous system depression such as drowsiness or respiratory system disorders.
  • Antacids containing aluminum or magnesium. This will result in a decrease in the absorption rate of gabapentin.
  • The effect is to lower the disposal of gabapentin from the kidneys.



  • Carbamazepine (Tegretol, Tegretol XR, Equetro, Carbatrol) reduces the effects of tramadol by increasing its inactivation in the body.
  • Quinidine (Quinaglute, Quinidex) reduces inactivation, increasing the concentration of tramadol by 50% to 60%.
  • Combining tramadol with monoamine oxidase or MAOI inhibitors can result in severe side effects such as seizures or a condition called serotonin syndrome.
  • Tramadol can improve the central nervous system and respiratory depression when combined with alcohol, anesthesia, narcotics, sedatives, or hypnotic sedatives. This can lower awareness levels or cause respiratory insufficiency.

Also find out about What Is Tramadol Used For. This drug has indeed been widely used, but you don’t know its true use.

Are Gabapentin and Tramadol Safe to Consume when Pregnant or Breastfeeding?


There is no adequate research regarding the risk of gabapentin use in pregnant or nursing mothers. Always consult a doctor to consider the potential benefits and risks before using this drug. Gabapentin falls into category C pregnancy risk according to the US Food and Drugs Administration (FDA)

Here is a reference to the category of pregnancy risk according to the FDA:

A: Not risky

B: Not at risk in some studies

C: Maybe at risk

D: There is positive evidence of risk

X: Contraindications

N: Unknown



Researchers have not proven tramadol safe during pregnancy. Nursing mothers should not take tramadol because babies can experience side effects, withdrawal symptoms, and difficulty breathing.


Can food or alcohol interact with Gabapentin?

Certain medications should not be used at the time of meals as drug interactions may occur. Consuming alcohol or tobacco with drugs can lead to interactions. For more details, you can find out on Mix Alcohol and Gabapentin: Know the Risk and Side Effects, Interactions and Dangers

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